TMO vs TSM: Which Is the Better Buy?
Side-by-side comparison of Thermo Fisher Scientific Inc. and Taiwan Semiconductor Manufacturing Company Limited — fair value, conviction, valuation metrics, and QuantHub research signals.
Updated 2026-09-23.
Thermo Fisher Scientific Inc. · Healthcare
$658.32
+31.1% upside to fair value
Med Conviction
Grade B
High Quality
VS
Taiwan Semiconductor Manufacturing Company Limited · Technology
$452.00
+13.9% upside to fair value
Med Conviction
Grade B
High Quality
QuantHub Verdict
TMO has more upside to fair value
(+31.1%).
These are model outputs — not personalized investment advice.
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Valuation & Fundamentals
| Metric |
TMO |
TSM |
| Current Price |
$658.32 |
$452.00 |
| Fair Value Estimate |
$863.34 |
$515.00 |
| Upside to Fair Value |
+31.1%
|
+13.9%
|
| Market Cap |
$244.7B |
$2,344.3B |
| Forward P/E |
—
|
—
|
| EV / EBITDA |
25.9x
|
19.2x
|
| Price / Sales |
5.3x
|
0.5x
|
| Price / FCF |
33.4x
|
2.1x
|
| Revenue Growth YoY |
+10.5%
|
+36.0%
|
| Gross Margin |
40.4%
|
64.2%
|
| Operating Margin |
17.7%
|
56.0%
|
| Return on Equity |
13.4%
|
39.3%
|
| Dividend Yield |
0.28% |
0.96% |
| FCF Yield |
3.0%
|
47.62%
|
| Analyst Consensus |
Strong Buy
|
Buy
|
Investment Thesis
Thermo Fisher Scientific is a global life-sciences and laboratory-services platform spanning Life Sciences Solutions, Analytical Instruments, Specialty Diagnostics, and Laboratory Products and Biopharma Services, with recognized brands including Thermo Scientific, Applied Biosystems, Invitrogen, Fisher Scientific, Patheon, and PPD, serving pharmaceutical, biotech, clinical, academic, and governme…
Taiwan Semiconductor Manufacturing Company is the world's largest contract chipmaker, manufacturing advanced logic, mixed-signal, RF, and embedded memory wafers for high-performance computing, smartphones, IoT, and automotive customers from a base of 65,152 employees headquartered in Hsinchu, Taiwan. The business quality is exceptionally high: TTM gross margin is 64.2%, TTM operating margin is 56…
Accumulation Zones
| Metric |
TMO |
TSM |
| Zone Low |
$647.50 |
$386.25 |
| Zone High |
$733.84 |
$437.75 |
| In Buy Zone? |
Yes
|
No
|