PFE vs TMO: Which Is the Better Buy?
Side-by-side comparison of Pfizer Inc. and Thermo Fisher Scientific Inc. — fair value, conviction, valuation metrics, and QuantHub research signals.
Updated 2026-09-18.
Pfizer Inc. · Healthcare
$27.64
+12.0% upside to fair value
Med Conviction
Grade B
VS
Thermo Fisher Scientific Inc. · Healthcare
$658.32
+31.1% upside to fair value
Med Conviction
Grade B
High Quality
QuantHub Verdict
TMO has more upside to fair value
(+31.1%).
These are model outputs — not personalized investment advice.
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Valuation & Fundamentals
| Metric |
PFE |
TMO |
| Current Price |
$27.64 |
$658.32 |
| Fair Value Estimate |
$30.94 |
$863.34 |
| Upside to Fair Value |
+12.0%
|
+31.1%
|
| Market Cap |
$157.5B |
$244.7B |
| Forward P/E |
—
|
—
|
| EV / EBITDA |
17.4x
|
25.9x
|
| Price / Sales |
2.5x
|
5.3x
|
| Price / FCF |
14.3x
|
33.4x
|
| Revenue Growth YoY |
+2.6%
|
+10.5%
|
| Gross Margin |
71.3%
|
40.4%
|
| Operating Margin |
25.1%
|
17.7%
|
| Return on Equity |
4.9%
|
13.4%
|
| Dividend Yield |
6.22% |
0.28% |
| FCF Yield |
6.97%
|
3.0%
|
| Analyst Consensus |
Hold
|
Strong Buy
|
Investment Thesis
Pfizer is a global biopharmaceutical leader with a portfolio spanning cardiovascular, oncology, vaccines, immunology, and rare disease, anchored by Eliquis, the Prevnar family, Vyndaqel, Ibrance, Xtandi, Comirnaty, and Paxlovid, and supported by roughly 75,000 employees and a contract manufacturing division. Business quality is medium rather than high: TTM gross margin of 71.3% and TTM operating …
Thermo Fisher Scientific is a global life-sciences and laboratory-services platform spanning Life Sciences Solutions, Analytical Instruments, Specialty Diagnostics, and Laboratory Products and Biopharma Services, with recognized brands including Thermo Scientific, Applied Biosystems, Invitrogen, Fisher Scientific, Patheon, and PPD, serving pharmaceutical, biotech, clinical, academic, and governme…
Accumulation Zones
| Metric |
PFE |
TMO |
| Zone Low |
$23.21 |
$647.50 |
| Zone High |
$26.30 |
$733.84 |
| In Buy Zone? |
No
|
Yes
|