ISRG vs PFE: Which Is the Better Buy?
Side-by-side comparison of Intuitive Surgical, Inc. and Pfizer Inc. — fair value, conviction, valuation metrics, and QuantHub research signals.
Updated 2026-04-22.
Intuitive Surgical, Inc. · Healthcare
$451.29
+130.4% upside to fair value
Grade B
High Quality
VS
Pfizer Inc. · Healthcare
$26.91
+30.1% upside to fair value
Med Conviction
Grade B+
QuantHub Verdict
ISRG has more upside to fair value
(+130.4%).
PFE trades at a lower forward P/E
(9.5x).
These are model outputs — not personalized investment advice.
See all research →
Valuation & Fundamentals
| Metric |
ISRG |
PFE |
| Current Price |
$451.29 |
$26.91 |
| Fair Value Estimate |
$1,039.74 |
$35.00 |
| Upside to Fair Value |
+130.4%
|
+30.1%
|
| Market Cap |
$160.3B |
$153.0B |
| Forward P/E |
53.8x
|
9.5x
|
| EV / EBITDA |
40.5x
|
13.8x
|
| Price / Sales |
15.2x
|
2.4x
|
| Price / FCF |
64.3x
|
16.8x
|
| Revenue Growth YoY |
+23.0%
|
-1.6%
|
| Gross Margin |
66.3%
|
70.3%
|
| Operating Margin |
30.5%
|
24.7%
|
| Return on Equity |
17.0%
|
9.0%
|
| Dividend Yield |
0% |
6.4% |
| FCF Yield |
1.55%
|
5.9%
|
| Analyst Consensus |
Strong Buy
|
Hold
|
Investment Thesis
Intuitive Surgical, Inc. is a leading healthcare company specializing in robotic-assisted surgery through its flagship da Vinci system, which has established a durable competitive moat with approximately 10,000 systems installed globally and nearly 17 million procedures performed by the end of 2024. The company benefits from a high-quality business model characterized by 85% recurring revenue, st…
Pfizer remains the world's largest traditional pharmaceutical company by non-COVID revenue, generating $62.6B in 2025 sales across oncology, cardiovascular, immunology, and vaccines. The stock trades at a P/S of 2.44x, still well below the 5-year median of 3.10x, driven by post-COVID revenue normalization, a $17-18B patent cliff spanning 2026-2028, and $61.6B in acquisition-related debt from Seag…
Accumulation Zones
| Metric |
ISRG |
PFE |
| Zone Low |
$779.81 |
$25.00 |
| Zone High |
$883.78 |
$29.00 |
| In Buy Zone? |
Yes
|
Yes
|