ISRG vs MELI: Which Is the Better Buy?

Side-by-side comparison of Intuitive Surgical, Inc. and MercadoLibre, Inc. β€” fair value, conviction, valuation metrics, and QuantHub research signals. Updated 2026-04-22.
Intuitive Surgical, Inc. Β· Healthcare
$451.29
+130.4% upside to fair value
Grade B High Quality
VS
MercadoLibre, Inc. Β· Consumer Cyclical
$1,767.42
+41.4% upside to fair value
High Conviction Grade A
QuantHub Verdict
ISRG has more upside to fair value (+130.4%). MELI trades at a lower forward P/E (35.0x). These are model outputs β€” not personalized investment advice. See all research β†’
Valuation & Fundamentals
Metric ISRG MELI
Current Price $451.29 $1,767.42
Fair Value Estimate $1,039.74 $2,500.00
Upside to Fair Value +130.4% +41.4%
Market Cap $160.3B $89.6B
Forward P/E 53.8x 35.0x
EV / EBITDA 40.5x 18.5x
Price / Sales 15.2x 3.1x
Price / FCF 64.3x 8.9x
Revenue Growth YoY +23.0% +39.1%
Gross Margin 66.3% 44.5%
Operating Margin 30.5% 11.1%
Return on Equity 17.0% 33.7%
Dividend Yield 0% 0%
FCF Yield 1.55% 12.1%
Analyst Consensus Strong Buy Strong Buy
Investment Thesis
ISRG β€” Intuitive Surgical, Inc.
Intuitive Surgical, Inc. is a leading healthcare company specializing in robotic-assisted surgery through its flagship da Vinci system, which has established a durable competitive moat with approximately 10,000 systems installed globally and nearly 17 million procedures performed by the end of 2024. The company benefits from a high-quality business model characterized by 85% recurring revenue, st…
MELI β€” MercadoLibre, Inc.
MercadoLibre is the dominant e-commerce and fintech ecosystem across Latin America, operating the largest marketplace and digital payments platform in a region with 670M+ people where e-commerce penetration is still under 15%. Revenue grew 39% to $28.9B in FY2025 with $10.8B in free cash flow β€” a 12% FCF yield at current prices. The company is trading at its 5-year P/S minimum (3.1x) and P/FCF mi…
Accumulation Zones
Metric ISRG MELI
Zone Low $779.81 $1,875.00
Zone High $883.78 $2,125.00
In Buy Zone? Yes Yes
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