HD vs TMO: Which Is the Better Buy?

Side-by-side comparison of The Home Depot, Inc. and Thermo Fisher Scientific Inc. โ€” fair value, conviction, valuation metrics, and QuantHub research signals. Updated 2026-07-13.
The Home Depot, Inc. ยท Consumer Cyclical
$343.30
+34.6% upside to fair value
Grade A High Quality
VS
Thermo Fisher Scientific Inc. ยท Healthcare
$464.61
+7.2% upside to fair value
Grade A High Quality
QuantHub Verdict
HD has more upside to fair value (+34.6%). HD trades at a lower forward P/E (24.3x). These are model outputs โ€” not personalized investment advice. See all research โ†’
Valuation & Fundamentals
Metric HD TMO
Current Price $343.30 $464.61
Fair Value Estimate $462.14 $498.27
Upside to Fair Value +34.6% +7.2%
Market Cap $342.3B $172.7B
Forward P/E 24.3x 25.2x
EV / EBITDA 16.5x 19.1x
Price / Sales 2.0x 3.8x
Price / FCF 23.9x 25.6x
Revenue Growth YoY +4.8% +6.2%
Gross Margin 33.1% 39.4%
Operating Margin 12.4% 17.8%
Return on Equity 113.3% 13.3%
Dividend Yield 0% 0%
FCF Yield 4.18% 3.91%
Analyst Consensus Buy Strong Buy
Investment Thesis
HD โ€” The Home Depot, Inc.
The Home Depot, Inc. operates as a leading home improvement retailer in the consumer cyclical sector, leveraging a strong brand and cost advantages to maintain a durable competitive moat. Despite a modest revenue growth of 4.8% and a decline in earnings by 4.2% in the most recent quarter, the company exhibits exceptional profitability metrics including a 113.3% return on equity and solid margins โ€ฆ
TMO โ€” Thermo Fisher Scientific Inc.
Thermo Fisher Scientific is a leading healthcare company specializing in life science tools, diagnostics, and contract research and manufacturing services. It operates with a broad, multi-layered moat driven by scale, integration, and a long-tenured management team. The company exhibits solid fundamentals with a 13.3% ROE, 6.2% revenue growth, and 9.6% earnings growth in the most recent quarter. โ€ฆ
Accumulation Zones
Metric HD TMO
Zone Low $346.61 $373.70
Zone High $392.82 $423.53
In Buy Zone? Yes No
โ† HD Research    TMO Research โ†’    All Research