HD vs TMO: Which Is the Better Buy?

Side-by-side comparison of The Home Depot, Inc. and Thermo Fisher Scientific Inc. โ€” fair value, conviction, valuation metrics, and QuantHub research signals. Updated 2026-05-04.
The Home Depot, Inc. ยท Consumer Cyclical
$337.34
+12.1% upside to fair value
Med Conviction Grade B
VS
Thermo Fisher Scientific Inc. ยท Healthcare
$462.60
+10.1% upside to fair value
Grade B
QuantHub Verdict
HD has more upside to fair value (+12.1%). HD trades at a lower forward P/E (23.0x). These are model outputs โ€” not personalized investment advice. See all research โ†’
Valuation & Fundamentals
Metric HD TMO
Current Price $337.34 $462.60
Fair Value Estimate $378.00 $509.20
Upside to Fair Value +12.1% +10.1%
Market Cap $336.0B $171.9B
Forward P/E 23.0x 25.1x
EV / EBITDA 18.1x 19.0x
Price / Sales 2.3x 3.8x
Price / FCF 29.7x 25.5x
Revenue Growth YoY +3.2% +6.2%
Gross Margin 33.3% 39.4%
Operating Margin 12.7% 17.8%
Return on Equity 110.5% 13.3%
Dividend Yield 2.44% 0%
FCF Yield 3.37% 3.92%
Analyst Consensus Buy Strong Buy
Investment Thesis
HD โ€” The Home Depot, Inc.
Home Depot remains the world's largest home improvement retailer with 2,350+ stores, dominant 52% market share, and a rapidly growing Pro contractor segment bolstered by the SRS Distribution acquisition. The stock has declined 21% from its $427 high to $337, but now trades at 2.28x P/S, near the 5-year median of 2.31x, and 26.5x P/E which is above the 5-year median of 23.5x. EPS declined 4.6% in โ€ฆ
TMO โ€” Thermo Fisher Scientific Inc.
Thermo Fisher Scientific Inc. operates in the healthcare sector, specializing in medical diagnostics and research tools across four main segments: Laboratory Products and Biopharma Services, Life Sciences Solutions, Analytical Instruments, and Specialty Diagnostics. The company demonstrates medium business quality with steady revenue growth of 6.2% and earnings growth of 9.6% in the most recent qโ€ฆ
Accumulation Zones
Metric HD TMO
Zone Low $285.00 $381.90
Zone High $320.00 $432.82
In Buy Zone? No No
โ† HD Research    TMO Research โ†’    All Research