HD vs PFE: Which Is the Better Buy?
Side-by-side comparison of The Home Depot, Inc. and Pfizer Inc. — fair value, conviction, valuation metrics, and QuantHub research signals.
Updated 2026-04-11.
The Home Depot, Inc. · Consumer Cyclical
$337.34
+12.1% upside to fair value
Med Conviction
Grade B
VS
Pfizer Inc. · Healthcare
$26.91
+30.1% upside to fair value
Med Conviction
Grade B+
QuantHub Verdict
PFE has more upside to fair value
(+30.1%).
PFE trades at a lower forward P/E
(9.5x).
These are model outputs — not personalized investment advice.
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Valuation & Fundamentals
| Metric |
HD |
PFE |
| Current Price |
$337.34 |
$26.91 |
| Fair Value Estimate |
$378.00 |
$35.00 |
| Upside to Fair Value |
+12.1%
|
+30.1%
|
| Market Cap |
$336.0B |
$153.0B |
| Forward P/E |
23.0x
|
9.5x
|
| EV / EBITDA |
18.1x
|
13.8x
|
| Price / Sales |
2.3x
|
2.4x
|
| Price / FCF |
29.7x
|
16.8x
|
| Revenue Growth YoY |
+3.2%
|
-1.6%
|
| Gross Margin |
33.3%
|
70.3%
|
| Operating Margin |
12.7%
|
24.7%
|
| Return on Equity |
110.5%
|
9.0%
|
| Dividend Yield |
2.44% |
6.4% |
| FCF Yield |
3.37%
|
5.9%
|
| Analyst Consensus |
Buy
|
Hold
|
Investment Thesis
Home Depot remains the world's largest home improvement retailer with 2,350+ stores, dominant 52% market share, and a rapidly growing Pro contractor segment bolstered by the SRS Distribution acquisition. The stock has declined 21% from its $427 high to $337, but now trades at 2.28x P/S, near the 5-year median of 2.31x, and 26.5x P/E which is above the 5-year median of 23.5x. EPS declined 4.6% in …
Pfizer remains the world's largest traditional pharmaceutical company by non-COVID revenue, generating $62.6B in 2025 sales across oncology, cardiovascular, immunology, and vaccines. The stock trades at a P/S of 2.44x, still well below the 5-year median of 3.10x, driven by post-COVID revenue normalization, a $17-18B patent cliff spanning 2026-2028, and $61.6B in acquisition-related debt from Seag…
Accumulation Zones
| Metric |
HD |
PFE |
| Zone Low |
$285.00 |
$25.00 |
| Zone High |
$320.00 |
$29.00 |
| In Buy Zone? |
No
|
Yes
|